The linkage map of sheep Chromosome 6 compared with orthologous regions in other species |
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Authors: | E A Lord J M Lumsden K G Dodds H M Henry A M Crawford H A Ansari P D Pearce D W Maher R T Stone S M Kappes C W Beattie G W Montgomery |
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Institution: | (1) AgResearch Molecular Biology Unit, Department of Biochemistry and Centre for Gene Research, University of Otago, P.O. Box 56, Dunedin, New Zealand, NZ;(2) AgResearch, Invermay Agricultural Centre, Private Bag 50034, Mosgiel, New Zealand, NZ;(3) AgResearch, Grasslands Research Centre, Private Bag 11008, Palmerston North, New Zealand, NZ;(4) United States Department of Agriculture, Agricultural Research Service, Roman L. Hruska U.S. Meat Animal Research Center, Clay Center, Nebraska, USA, US |
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Abstract: | The genetic linkage map of sheep Chromosome (Chr) 6 has been extended to include 35 loci with the addition of 11 RFLP and
12 microsatellite loci. The sex-averaged linkage map now spans 154 cM from phosphodiesterase cyclic GMP beta polypeptide (PDE6B) to OarCP125, an anonymous sheep microsatellite. The male and female map lengths, at 180 cM and 132 cM respectively, did not differ significantly.
The physical assignment of PDE6B to Chr 6q33-qter orientates the linkage map on sheep Chr 6 with PDE6B near the telomere and OarCP125 towards the centromere. The order and genetic distances between loci are similar for the sheep Chr 6 and cattle Chr 6 maps,
except for the position of the casein genes. The sheep Chr 6 linkage map is also comparable to portions of human Chr 4, mouse
Chrs 5 and 3, and pig Chr 8. The synteny between sheep Chr 6 and human Chr 4 has been extended from PDE6B (4p16.3) to epidermal growth factor (EGF, 4q25-q27). However, a region from platelet-derived growth factor receptor α polypeptide (PDGFRA) to bone morphogenetic protein 3 (BMP3), which spans 19 cM on sheep Chr 6, appears to be inverted with respect to the human and mouse loci. Other differences in
the gene order between sheep, pig, and mouse suggest more complex rearrangements.
Received: 16 August 1995 / Accepted: 12 December 1995 |
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