Estimation of Incremental Unit Risks for Inhaled Nickel Subsulfide and Nickel Oxide,Based on a Combination of Human and Animal Data

Both animal and human exposure–response data are used to estimate the incremental unit risks (IURs) of lung cancer for Ni₃S₂ and NiO, which are constituent compounds of nickel refinery dust. The animal experiments are used to determine relative lung cancer potencies for Ni₃S₂ and NiO, and the human epidemiological data are used as the best estimate of overall risk for refinery dust exposure. The animal data for Ni₃S₂ are fit with a linear model, while the nonlinear animal data for NiO are fit with a Weibull model. The lower 95% confidence limit at a 5% point of departure is used to calculate a tumorigenic potency ratio of Ni₃S₂ to NiO of 5.6. Analyses of actual nickel refinery dust indicate the weight% of Ni₃S₂ and NiO to be 82% and 9%, respectively. This information is used with the previously determined IUR for nickel refinery dust to calculate IUR_NiO = 5.1 × 10^?5 (μg Ni/m³)^?1 and IUR_Ni3S2 = 2.9 × 10^?4 (μg Ni/m³)^?1.