Influence of Cu2+ on the Amino Acids Profile of Saccharomyces cerevisiae RD1 during Growth

The growth and the amino acid composition of the strain Saccharomyces cerevisiae RD1 were studied in the presence of copper ions. The accumulation of biomass was inhibited with the increase of Cu²⁺ concentration. It should be noted that the synthesis of aromatic amino acids was promoted at lower Cu²⁺ concentration (100 mg·L^?1), but at higher concentrations the inhibiting effect was significant. The decreases of the amino acid contents with the increase of Cu²⁺ concentration varied upon their type. The total amount of amino acids was much lower at 300 and 400 mg·L^?1 Cu²⁺.