In vivo and in vitro catabolism of native and biologically modified LDL |
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Authors: | J F Nagelkerke L Havekes V W van Hinsbergh T J van Berkel |
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Institution: | Institut für Botanik der Universität Regensburg, Universitätsstraße 31, D-8400 Regensburg, FRG |
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Abstract: | Incubation of human low density lipoprotein (LDL) at 37 degrees C in the presence of human umbilical-vein endothelial cells (EC) causes a time-dependent shift in the charge and density of LDL. After intravenous injection into rats, native LDL is merely cleared from the circulation by Kupffer cells while EC-modified LDL is rapidly cleared by endothelial liver cells. The uptake of native LDL by Kupffer cells and EC-modified LDL by endothelial cells in vivo can be explained by the presence of two different specific receptors on these cell types. It is concluded that the liver endothelial cells form an important protection against a possible atherogenic action of EC-modified LDL. |
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Keywords: | Electron transport Membrane protein Reaction center P840 Bacterial photosynthesis |
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