Complex inheritance and localizing disease genes. |
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Authors: | J J Hoh J Ott |
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Institution: | Division of Biostatistics, Columbia University, Rockefeller University, New York, NY 10021-6399, USA. |
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Abstract: | Most methods for localizing genes underlying complex traits work under the implicit or explicit assumption of a single disease gene with the possible exception of heterogeneity, that is, different disease genes in different families. We discuss current single-locus and multi-locus methods. Novel approaches are proposed that take into account all marker loci over the genome. A simple example is given for an unconventional statistic, i.e. the mean of allele sharing over all markers on a chromosome. |
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