Evaluation of Body Composition in Patients With and Without Adrenal Tumors and Without Overt Hypersecretory Syndromes |
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| Institution: | 1. Department of Endocrinology and Nutrition, Ramón y Cajal University Hospital, Madrid, Spain;2. Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain;3. Department of Medicine, Universidad de Alcalá, Madrid, Spain;4. Department of Biochemistry, Ramón y Cajal University Hospital, Madrid, Spain;5. Department of Biochemistry and Molecular Genetics, Hospital Clinic, Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Barcelona, Spain;6. Department of Endocrinology and Nutrition. Hospital Clinic, IDIBAPS, Barcelona, Spain;7. Department of Diagnostic Imaging, Ramón y Cajal University Hospital, Madrid, Spain;8. Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain |
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| Abstract: | ObjectiveTo compare body composition between patients with autonomous cortisol secretion (ACS), those with nonfunctioning adrenal incidentalomas (NFAIs), and control subjects without adrenal tumors.MethodsA cross-sectional study was performed, incluidng the following 3 groups: patients with ACS (cortisol post–dexamethasone suppression test DST] >1.8 μg/dL), NFAIs (cortisol post-DST ≤ 1.8 μg/dL), and patients without adrenal tumors (control group). Patients of the 3 groups were matched according to age (±5 years), sex, and body mass index (±5 kg/m2). Body composition was evaluated by bioelectrical impedance and abdominal computed tomography (CT) and urinary steroid profile by gas chromatography mass spectrometry.ResultsThis study enrolled 25 patients with ACS, 24 with NFAIs, and 24 control subjects. Based on CT images, a weak positive correlation between the serum cortisol level post-DST and subcutaneous fat area (r = 0.3, P =.048) was found. As assessed by bioelectrical impedance, lean mass and bone mass were positively correlated with the excretion of total androgens (r = 0.56, P <.001; and r = 0.58, P <.001, respectively); visceral mass was positively correlated with the excretion of glucocorticoid metabolites and total glucocorticoids (r = 0.28, P =.031; and r = 0.42, P =.001, respectively). Based on CT imaging evaluation, a positive correlation was observed between lean mass and androgen metabolites (r = 0.30, P =.036) and between visceral fat area, total fat area, and visceral/total fat area ratio and the excretion of glucocorticoid metabolites (r = 0.34, P =.014; r = 0.29, P =.042; and r = 0.31, P =.170, respectively).ConclusionThe urinary steroid profile observed in adrenal tumors, comprising a low excretion of androgen metabolites and high excretion of glucocorticoid metabolites, is associated with a lower lean mass and bone mass and higher level of visceral mass in patients with adrenal tumors. |
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| Keywords: | adrenal tumors autonomous cortisol secretion nonfunctioning adrenal incidentalomas body mass composition bioelectrical impedance metabolomics ACS"} {"#name":"keyword" "$":{"id":"kwrd0040a"} "$$":[{"#name":"text" "_":"autonomous cortisol secretion AIs"} {"#name":"keyword" "$":{"id":"kwrd0050b"} "$$":[{"#name":"text" "_":"adrenal incidentalomas BMI"} {"#name":"keyword" "$":{"id":"kwrd0060c"} "$$":[{"#name":"text" "_":"body mass index CT"} {"#name":"keyword" "$":{"id":"kwrd0060d"} "$$":[{"#name":"text" "_":"computed tomography DST"} {"#name":"keyword" "$":{"id":"kwrd0060f"} "$$":[{"#name":"text" "_":"dexamethasone suppression test NFAI"} {"#name":"keyword" "$":{"id":"kwrd0060h"} "$$":[{"#name":"text" "_":"non-functioning adrenal incidentalomas SFA"} {"#name":"keyword" "$":{"id":"kwrd0060j"} "$$":[{"#name":"text" "_":"subcutaneous fat area TFA"} {"#name":"keyword" "$":{"id":"kwrd0060l"} "$$":[{"#name":"text" "_":"total fat area USP"} {"#name":"keyword" "$":{"id":"kwrd0060n"} "$$":[{"#name":"text" "_":"urinary steroid profile VFA"} {"#name":"keyword" "$":{"id":"kwrd0060p"} "$$":[{"#name":"text" "_":"visceral fat area |
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