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GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis
Affiliation:1. Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea;2. Division of Translational Science, Research Institute and Hospital, National Cancer Center, Goyang 10408, Republic of Korea;3. Korea Brain Research Institute (KBRI), Daegu 41062, Republic of Korea;4. Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea;5. Electron Microscopy Research Center, Korea Basic Science Institute (KBSI), Cheongju 28119, Republic of Korea;6. Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Republic of Korea
Abstract:
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  • Keywords:GPR143  HRS  exosomal protein sorting  exosome biogenesis  MVB  melanoma  breast cancer  metastasis
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