Structural Diversity of Eukaryotic Membrane Cytochrome P450s |
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| Authors: | Eric F. Johnson C. David Stout |
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| Affiliation: | From the Departments of ‡Molecular and Experimental Medicine and ;§Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037 |
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| Abstract: | X-ray crystal structures are available for 29 eukaryotic microsomal, chloroplast, or mitochondrial cytochrome P450s, including two non-monooxygenase P450s. These structures provide a basis for understanding structure-function relations that underlie their distinct catalytic activities. Moreover, structural plasticity has been characterized for individual P450s that aids in understanding substrate binding in P450s that mediate drug clearance. |
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| Keywords: | Carcinogenesis Cytochrome P450 Drug Development Drug Metabolism Protein structure Steroidogenesis |
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