|
|||||
|
|
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis |
|
| Authors: | Sakine Simsekyilmaz Fabian Schreiber Stefan Weinandy Felix Gremse Tolga Taha S?nmez Elisa A Liehn |
| Institution: | 1.Institute for Molecular Cardiovascular Research, RWTH Aachen University;2.Institute for Textile Technology and Mechanical Engineering, RWTH Aachen University;3.Institute for Applied Medical Engineering, Helmholtz-Institute of RWTH Aachen University;4.Department of Experimental Molecular Imaging, RWTH Aachen University;5.Department of Oral and Maxillofacila Surgery, RWTH Aachen University |
| Abstract: | Despite the considerable progress made in the stent development in the last decades, cardiovascular diseases remain the main cause of death in western countries. Beside the benefits offered by the development of different drug-eluting stents, the coronary revascularization bears also the life-threatening risks of in-stent thrombosis and restenosis. Research on new therapeutic strategies is impaired by the lack of appropriate methods to study stent implantation and restenosis processes. Here, we describe a rapid and accessible procedure of stent implantation in mouse carotid artery, which offers the possibility to study in a convenient way the molecular mechanisms of vessel remodeling and the effects of different drug coatings. |
| Keywords: | Medicine Issue 75 Anatomy Physiology Biomedical Engineering Mechanical Engineering Cardiology Surgery Microsurgery Animal Experimentation Models Animal Cardiovascular Diseases Stent implantation atherosclerosis restenosis in-stent thrombosis stent mouse carotid artery arteries blood vessels mouse animal model surgical techniques |