Production of l-carnitine from d-carnitine by dried cells of Agrobacterium sp. 525a |
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| Affiliation: | 1. FP-ENAS-Faculdade de Ciências de Saúde, Escola Superior de Saúde da UFP, Universidade Fernando Pessoa, Rua Carlos da Maia, 296, P-4200-150 Porto, Portugal,;2. LAQV, REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre, 687, P-4169-007 Porto, Portugal,;3. Department of Chemistry, University of Aberdeen, Meston Walk, Old Aberdeen AB24 3UE, Scotland;4. Instituto de Tecnologia em Fármacos e Farmanguinhos, Fundação Oswaldo Cruz, 21041-250 Rio de Janeiro, RJ, Brazil;1. Education Ministry Key Laboratory of Integrated Management of Crop Diseases and Pests, College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China;2. Department of Plant Protection, Xinjiang Academy of Agricultural Sciences, Urumqi 830091, China |
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| Abstract: | d-Carnitine was converted into l-carnitine with dried cells of Agrobacterium sp. 525a grown on d-carnitine medium. During the conversion reaction, NAD+ concentration decreased. o-Phenanthroline inhibited the NAD+ degrading activity in dried cells, and the formation of l-carnitine increased 2.8 times. About 190 mM of l-carnitine was converted from 0.5 M of d-carnitine under the best conditions. |
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