Stimulation of dieldrin elimination by a thiouracil derivative and DDT in the rat: Enhancement of dieldrin oxidative metabolism? |
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| Authors: | W Pearl D Kupfer |
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| Affiliation: | Lederle Laboratories, Division of American Cyanamid Company, Pearl River, N. Y. 10965 U.S.A. |
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| Abstract: | Oral treatment of rats with either DDT or 1-benzyl-2-thio-5,6-dihydrouracil (BTDU) enhanced the elimination of intraperitoneally administered [14C]dieldrin. Both DDT and BTDU caused a severalfold increase in the urinary elimination of [14C]dieldrin. The increase in [14C]dieldrin elimination in the feces was less pronounced. |
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| Keywords: | BTDU, 1-benzyl-2-thio-5,6-dihydrouracil dimethyl POPOP 1,4-bis[2-(4-methyl-5-phenyloxazolyl)]-benzene i.p., intraperitoneally |
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