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Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4) |
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| Authors: | Wang Ying Zhang Yingmei Yang Xue Han Wenling Liu Yanan Xu Qianmei Zhao Rui Di Chunhui Song Quansheng Ma Dalong |
| Institution: | Center for Human Disease Genomics, Peking University, Beijing, PR China. |
| Abstract: | Chemokine-like factor 1 (CKLF1) exhibits chemotactic effects on leukocytes. Its amino acid sequence shares similarity with those of TARC/CCL17 and MDC/CCL22, the cognate ligands for CCR4. The chemotactic effects of CKLF1 for CCR4-transfected cells could be desensitized by TARC/CCL17 and markedly inhibited by PTX. CKLF1 induced a calcium flux in CCR4-transfected cells and fully desensitized a subsequent response to TARC/CCL17, and TARC/CCL17 could partly desensitize the response to CKLF1. CKLF1 caused significant receptor internalization in pCCR4-EGFP transfected cells. Taken together, CKLF1 is a novel functional ligand for CCR4. |
| Keywords: | CKLF Chemokine-like factor CCR CC chemokine receptor TARC Thymus- and activation-regulated chemokine MDC Macrophage-derived chemokine MIP-3α Macrophage inflammatory protein 3α HRP Horseradish peroxidase CLF Chemokine-like functions |
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