Longitudinal analysis of the vaginal microflora in pregnancy suggests that L. crispatus promotes the stability of the normal vaginal microflora and that L. gasseri and/or L. iners are more conducive to the occurrence of abnormal vaginal microflora |
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| Authors: | Hans Verstraelen Rita Verhelst Geert Claeys Ellen De Backer Marleen Temmerman Mario Vaneechoutte |
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| Institution: | (1) Department of Obstetrics & Gynaecology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium;(2) Laboratory Bacteriology Research, Department of Clinical Chemistry, Microbiology and Immunology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium;(3) Department of Clinical Chemistry, Microbiology, and Immunology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium |
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| Abstract: | Background Despite their antimicrobial potential, vaginal lactobacilli often fail to retain dominance, resulting in overgrowth of the
vagina by other bacteria, as observed with bacterial vaginosis. It remains elusive however to what extent interindividual
differences in vaginal Lactobacillus community composition determine the stability of this microflora. In a prospective cohort of pregnant women we studied the
stability of the normal vaginal microflora (assessed on Gram stain) as a function of the presence of the vaginal Lactobacillus index species (determined through culture and molecular analysis with tRFLP). |
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