Variation in basal heat shock protein 70 is correlated to core temperature in human subjects |
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Authors: | Marie E Sandström Leigh A Madden Lee Taylor Jason C Siegler Ric J Lovell Adrian Midgley Lars McNaughton |
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Institution: | (1) Department of Sport, Health and Exercise Science, University of Hull, Cottingham Road, Hull, HU6 7RX, UK;(2) Post Graduate Medical Institute, University of Hull, Cottingham Road, Hull, HU6 7RX, UK; |
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Abstract: | Heat shock proteins are highly conserved proteins and play an important chaperone role in aiding the folding of nascent proteins
within cells. The heat shock protein response to various stressors, both in vitro and in vivo, is well characterised. However,
basal levels of heat shock protein 70 (Hsp70) have not previously been investigated. Monocyte-expressed Hsp70 was determined
every 4 h, over a 24 h time period, in 17 healthy male subjects (177 ± 6.4 cm, 75.7 ± 10.9 kg, 19.8 ± 4.3 years) within a
temperature and activity controlled environment. Core temperature was measured at 5-min intervals during the 24 h period.
Hsp70 showed significant diurnal variation (F = 7.4; p < 0.001), demonstrating peaks at 0900 and 2100 hours, and a nadir at 05.00. Core temperature followed a similar temporal
trend (range = 35.96–38.10°C) and was significantly correlated with Hsp70 expression (r
s = 0.44; p < 0.001). These findings suggest a high responsiveness of Hsp70 expression in monocytes to slight variations in core temperature. |
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