A combination of methotrexate and zoledronic acid prevents bone erosions and systemic bone mass loss in collagen induced arthritis |
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| Authors: | Benoit Le Goff Elise Soltner Céline Charrier Yves Maugars Fran?oise Rédini Dominique Heymann Jean-Marie Berthelot |
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| Institution: | (1) INSERM UMR-S 957, 1 rue Gaston Veil, 44035 Nantes Cedex 1, France;(2) Nantes atlantique universit?s, Laboratoire de Physiopathologie de la R?sorption Osseuse et Th?rapie des Tumeurs Osseuses Primitives, EA3822, Universit? de Nantes, 1 rue Gaston Veil, 44035 Nantes Cedex 1, France;(3) Rheumatology Unit, H?tel-Dieu, Nantes University Hospital, 1 place Alexis Ricordeau, 44093 Nantes Cedex 1, France;(4) P?le de Biologie, H?tel Dieu, Nantes University Hospital, 1 place Alexis Ricordeau, 44093 Nantes Cedex 1, France |
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| Abstract: | Introduction Osteoclasts play a key role in the pathogenesis of bone erosion and systemic bone mass loss during rheumatoid arthritis (RA).
In this study, we aimed to determine the effect of methotrexate (MTX) and zoledronic acid (ZA), used alone or in combination,
on osteoclast-mediated bone erosions and systemic bone mass loss in a rat model of collagen induced arthritis (CIA). We hypothesized
that MTX and ZA could have an additive effect to prevent both bone erosion and systemic bone loss. |
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