Nickel (II) complexes of naphthaquinone thiosemicarbazone and semicarbazone: synthesis, structure, spectroscopy, and biological activity |
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| Authors: | Afrasiabi Zahra Sinn Ekk Lin Weisheng Ma Yinfa Campana Charles Padhye Subhash |
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| Institution: | Department of Chemistry, University of Missouri-Rolla, Rolla, MO 65409, USA. za347@umr.edu |
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| Abstract: | Ni(II) complexes of ortho-naphthaquinone thiosemicarbazone and semicarbazone were synthesized and spectroscopically characterized. The X-ray crystal structure of both the complexes describe a distorted octahedral coordination with two tridentate mono-deprotonated ligands. In vitro anticancer studies on MCF-7 human breast cancer cells reveal that the semicarbazone derivative along with its nickel complex is more active in the inhibition of cell proliferation than the thiosemicarbazone analogue. |
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