Cycles within cycles: the interplay between differentiation and cell division in Trypanosoma brucei

The life cycle o f the African trypanosome is divided between the mammal and the tsetse. Those life cycle stages which traverse between these two hosts appear to be pre-adopted for survival in their new habitat They are also non-dividing. Here, Keith Matthews and Keith Gull discuss how and why trypanosomes might enmesh the control o f their cell cycle with their regulation o f the transition between different life cycle forms.