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Pyridazines. Part 36: Synthesis and antiplatelet activity of 5-substituted-6-phenyl-3(2H)-pyridazinones |
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| Authors: | Coelho Alberto Sotelo Eddy Fraiz Nuria Yáñez Matilde Laguna Reyes Cano Ernesto Raviña Enrique |
| Affiliation: | Departamento de Qui;mica Orgánica, Laboratorio de Qui;mica Farmacéutica, Drug Research & Development Group, Universidade de Santiago de Compostela, 15782-, Santiago de Compostela, Spain. |
| Abstract: | A convenient and efficient palladium-catalysed retro-ene-assisted method has been developed to prepare a series of 5-substituted-6-phenyl-3(2H)-pyridazinones as potential antiplatelet drugs. The most active compounds were those that contain a 3-phenyl-3-oxo-propenyl fragment or a phenylthio group at position 5 of the heterocyclic ring. |
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