Cardiopulmonary responses to Pseudomonas septicemia in swine: an improved model of the adult respiratory distress syndrome |
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| Authors: | R A Mustard J Fisher S Hayman A Matlow J B Mullen J Odumeru M W Roomi B D Schouten H T Swanson |
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| Institution: | Department of Surgery, Wellesley Hospital, Toronto, Ontario, Canada. |
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| Abstract: | Bacteremia with resultant damage to multiple organ systems remains a serious problem in intensive care of human patients. We have developed a clinically relevant swine model of sepsis-induced adult respiratory distress syndrome (ARDS). Twenty-three animals were given various doses of Pseudomonas aeruginosa intravenously. Low cardiac output septic shock was prevented with massive fluid infusion. It was found that a dose of 1.0 X 10(7) colony forming units per 20 kg/min for 2 hours reliably produced respiratory failure in a setting of hyperdynamic sepsis which meets the diagnostic criteria of human ARDS. |
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