Interactions among nickel,copper, and iron in rats |
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Authors: | Forrest H Nielsen Thomas J Zimmerman Terrence R Shuler |
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Institution: | (1) United States Department of Agriculture, Agriculture Research Service, Grand Forks Human Nutrition Research Center, University of North Dakota, 58202 Grand Forks, North Dakota;(2) Department of Biochemistry, University of North Dakota, 58202 Grand Forks, North Dakota |
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Abstract: | In two fully crossed, three-way, two by three by three, factorially arranged experiments, female weanling rats were fed a
basal diet supplemented with iron at 15 and 45 μg/g, nickel at 0, 5, and 50 μg/g and copper at 0, 0.5, and 5 μg/g (Expt. 1)
or 0, 0.25, and 12 μg/g (Expt. 2). Expt. 1 was terminated at 11 weeks, and Expt. 2 at 8 weeks because, at those times, some
rats fed no supplemental copper and the high level of nickel began to lose weight, or die from heart rupture. The experiments
showed that nickel interacted with copper and this interaction was influenced by dietary iron. If copper deficiency was neither
very severe or mild, copper deficiency signs of elevated levels of total lipids and lipid phosphorus in liver and plasma,
and cholesterol in plasma, were made more severe by supplemental dietary nickel. Rats in which nickel supplementation exacerbated
copper deficiency did not exhibit a depressed level of copper in liver and plasma. Also, although iron deprivation enhanced
the interaction between nickel and copper, iron deprivation did not significantly depress the level of copper in liver and
plasma. The findings confirmed that, in rats, a complex relationship exists between nickel, copper, and iron, thus indicating
that both the iron and copper status of experimental animals must be controlled before data about nickel nutriture and metabolism
can be compared among studies. |
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Keywords: | Nickel interaction with copper and iron copper interaction with nickel and iron iron interaction with nickel and copper nickel-copper-iron interactions liver lipids and trace elements in plasma lipids and trace elements in lipids effect of trace elements on liver and plasma contents of |
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