Suppressor cell clones specific for ultraviolet radiation-induced tumors. Function and surface proteins |
| |
Authors: | J Trial B W McIntyre |
| |
Affiliation: | Department of Immunology, University of Texas M. D. Anderson Cancer Center, Houston 77030. |
| |
Abstract: | Lymphocytes were cloned from animals bearing UV-induced skin tumors. These cells were I-J+, CD4-, CD8-, and had become growth factor independent. Extracts, but not supernatants, of these clones suppressed primary immune reactions in vitro against UV-induced tumors, but not methylcholanthrene-induced tumors. The cells therefore had the functional characteristics of afferent suppressor T cells directed against a common Ag on UV-induced tumors. Surface iodination of the clones revealed an extremely low level expression of molecules that might be TCR or related molecules. |
| |
Keywords: | |
|
|