Structural and mechanical properties of TTR105-115 amyloid fibrils from compression experiments |
| |
Authors: | Meersman Filip Cabrera Raúl Quesada McMillan Paul F Dmitriev Vladimir |
| |
Affiliation: | †Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium;‡Department of Chemistry, University College London, London, United Kingdom;§Swiss-Norwegian Beamlines at ESRF, Boite Postale 220, F-38043 Grenoble, France |
| |
Abstract: | Amyloid fibrils, originally associated with neurodegenerative diseases, are now recognized to have interesting mechanical properties. By using synchrotron x-ray diffraction at high pressure in a diamond anvil cell we determined the bulk modulus of TTR105-115 amyloid fibrils in water and in silicone oil to be 2.6 and 8.1 GPa, respectively. The compression characteristics of the fibrils are quite different in the two media, revealing the presence of cavities along the axis of the fibrils, but not between the β-sheets, which are separated by a dry interface as in a steric zipper motif. Our results emphasize the importance of peptide packing in determining the structural and mechanical properties of amyloid fibrils. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|