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Optimization of a screening lead for factor VIIa/TF |
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| Authors: | Young W B Kolesnikov A Rai R Sprengeler P A Leahy E M Shrader W D Sangalang J Burgess-Henry J Spencer J Elrod K Cregar L |
| Affiliation: | Department of Medicinal Chemistry, Axys Pharmaceuticals, Inc., 385 Oyster Point Blvd., South San Francisco, CA 94080, USA. wendy_young@axyspharm.com |
| Abstract: | The structure-based design and progression of a screening lead to a 3nM factor VIIa/TF inhibitor with improved selectivity versus related enzymes is described. |
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