细菌SGNH家族水解酶的研究进展

SGNH水解酶家族是一类在四个保守序列区上具有严格保守催化残基Ser、Gly、Asn和His的水解酶,该家族水解酶广泛存在于真核生物和原核生物中。细菌来源的SGNH水解酶家族具有来源广泛、功能多样且催化机制独特等特点,在细菌致病性、碳源代谢和天然产物合成等方面发挥重要生物学功能,在医药、化工、生物燃料和环境修复等领域具有广泛的应用潜力。本文从氨基酸序列、蛋白结构特征、酶学催化机制、细菌生理功能及应用领域等方面对细菌来源的SGNH水解酶家族成员进行综述。

Progress in bacterial SGNH family hydrolases

The SGNH hydrolase family consists of enzymes possessing four strictly conserved catalytic residues Ser, Gly, Asn and His in four conserved blocks, respectively, which are widespread in eukaryotes and prokaryotes. Bacterial SGNH family hydrolases are widely distributed and versatile with unique catalytic mechanisms. They play important roles in many biological processes such as bacterial virulence, carbon source metabolism and natural product synthesis. The enzymes also cover a broad spectrum of biotechnological applications in medicine, chemical engineering, biofuel, environmental bioremendiation, etc. The present review describes the amino acid sequence, protein structure, catalytic mechanism, physiological function and application potential of bacterial SGNH family hydrolases.