Telomere and ribosomal DNA repeats are chromosomal targets of the bloom syndrome DNA helicase期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Telomere and ribosomal DNA repeats are chromosomal targets of the bloom syndrome DNA helicase

Authors:	James?Schawalder,Enesa?Paric,Norma?F?Neff author-information" > author-information__contact u-icon-before" > mailto:nneff@usa.net" title=" nneff@usa.net" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) Laboratory of Molecular Genetics, New York Blood Center, New York, New York 10021, USA;(2) Helicon Therapeutics, Farmingdale, New York, 11735, USA;(3) Gene Therapy Vector Laboratory, North Shore University Hospital, New York, New York 11030, USA

Abstract:	Background Bloom syndrome is one of the most cancer-predisposing disorders and is characterized by genomic instability and a high frequency of sister chromatid exchange. The disorder is caused by loss of function of a 3' to 5' RecQ DNA helicase, BLM. The exact role of BLM in maintaining genomic integrity is not known but the helicase has been found to associate with several DNA repair complexes and some DNA replication foci.

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