水/乙醇混合溶剂中的阿奇霉素结晶动力学

利用粒数密度和粒度之间的关系判别晶体生长模型;采用间歇动态法,以粒数衡算方程、溶质质量守恒和McCabe定律为基础,利用Beer-Lambert定律,借助光学关联的方法,建立了包含透光率变量的伴有成核和晶体生长的动力学模型;通过在线测量溶液密度与透光率数据,采用非线性最小二乘法拟合得到了晶体成核和生长动力学经验方程,并以实时浓度为目标验证了动力学参数的准确性以及模型表达式的正确性。

Crystallization kinetics of azithromycin in mixture solvents of water and ethanol

The type of crystal growth model was determined by the relationship between the particle density and the particle population distribution. Based on the population balance equation, the solute mass conservation law and the McCabe law, the crystallization process of azithromycin was explored. With the help of optical correlation method based on the Beer-Lambert law, the kinetics models concerning the nucleation and crystal growth related to transmittance were established and the test variables of the solid- liquid phase information were given. The solution density and the transmittance rate were measured on- line. The kinetics parameters of crystal growth and nucleation were calculated by nonlinear least-squares regression. Finally, the kinetics parameters and the model expressions were verified by real-time concentration. The results could provide theoretical guide to simulate and optimize the crystallization process, thus obtaining available crystal form of azithromycin.