Synthesis,antioxidative and antiviral activity of hydroxycinnamic acid amides of thiazole containing amino acid |
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Authors: | Ivanka Stankova Kiril Chuchkov Stoyan Shishkov Kalina Kostova Luchia Mukova Angel S. Galabov |
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Affiliation: | (1) Department of Chemistry, South-West University “Neofit Rilski”, 2700 Blagoevgrad, Bulgaria;(2) Laboratory of Virology, Faculty of Biology, St. Kl. Ohridski Sofia University, 1164 Sofia, Bulgaria;(3) Bulgarian Academy of Sciences, The Stephan Angeloff Institute of Microbiology, 1113 Sofia, Bulgaria |
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Abstract: | The synthesis and the biological (antioxidant and antiviral) activities of novel hydroxycinnamic acid amides of a thiazole containing TFA.valine-4-carboxylic acid ethyl ester are reported. The amides have been synthesized from p-coumaric, ferulic and sinapic acids with the corresponding TFA.valine-thiazole-4-carboxylic acid ethyl ester using the coupling reagent N-ethyl-N′-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and 4-(dimethylamino) pyridine (DMAP) as a catalyst. The antioxidant properties of the newly synthesized amides have been studied for then antioxidative activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH)* test. The newly synthesized compounds have been tested against the replication in vitro of influenza virus A (H3N2) and human herpes virus 1 and 2 (HSV-1 and HSV-2). |
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