Increasingly irritable and close to tears: TRPA1 in inflammatory pain |
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Authors: | McMahon Stephen B Wood John N |
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Institution: | London Pain Consortium, King's College London, London WC2R 2LS, United Kingdom. stephen.mcmahon@kcl.ac.uk |
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Abstract: | TRP cation channels transduce mechanical, thermal, and pain-related inflammatory signals. In this issue of Cell, it is reported that TRPA1 has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, including those found in tear gas and garlic. In contrast, mechano- and thermosensation are normal in TRPA1-deficient mice. |
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