Prostaglandin production and lipolysis in isolated rat adipocytes as affected by dietary fat |
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Authors: | Barbara A. Lipinski Melvin M. Mathias |
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Affiliation: | Department of Food Science and Nutrition Colorado Statue University Fort Collins, Colorado 80523 USA |
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Abstract: | The influence of dietary fat on prostaglandin production and lipolysis was tested in basal and norepinephrine stimulated adipocytes isolated from the epididymal fat pads of fasted rats. Seven diets varying in fat calories and polyunsaturation were utilized. No basal differences were noted for prostaglandin E2 production or lipolysis. Norepinephrine stimulated prostaglandin E2 and F2α production was significantly (P < 0.01) increased with greater polyunsaturation of fat, but not by increased fat calories. Norepinephrine stimulated lipolysis was depressed by an increase in fat calories but was unaffected by the degree of polyunsaturation of fat. This is in vitro evidence against the concept that prostaglandins play a feedback regulator role in fat cell lipolysis since no correlation could be made between the two parameters. |
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