The effect of gramicidin A on phospholipid bilayers |
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Authors: | B. A. Cornell L. E. Weir F. Separovic |
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Affiliation: | (1) CSIRO Division of Food Research, P.O. Box 52, 2113 North Ryde, NSW, Australia |
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Abstract: | The helical polypeptide, gramicidin A has been widely studied as a model for the interactions of hydrophobic proteins with lipid bilayer membranes. Many reports are now available of the physical effects of mixing gramicidin A with phospholipid membranes, however, the interpretation of these data remains unclear. The purpose of this communication is to examine the controversial claim that high concentrations of gramicidin A cause disorder within the L phase of phosphatidylcholine-water dispersions. Solid-state nuclear magnetic resonance (NMR), density gradient and X-ray diffraction techniques are used to confirm the existence of such an effect and mechanisms are discussed which account for the known effects of gramicidin A on lipid bilayers. |
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Keywords: | Lipid-protein interactions gramicidin A /content/q731x49576520741/xxlarge8242.gif" alt=" prime" align=" BASELINE" BORDER=" 0" > integral membrane polypeptide |
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