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Efficient synthesis of 'redox-switched' naphthoquinone thiol-crown ethers and their biological activity evaluation
Authors:Huang Sheng Tung  Kuo Hsien Shou  Hsiao Chiao Long  Lin Yuh Ling
Institution:Department of Biochemistry, Taipei Medical University, Taipei, Taiwan.
Abstract:Series of naphthoquinone thiol-crown ethers had been prepared. The antibacterial, antifungal, and cytotoxic activities of these synthetic naphthoquinone thiol-crown ethers were investigated. All of the compounds tested displayed antibacterial, cytotoxic and antifungal activities. The bis-naphthoquinone thiol-crown ether 7a was the most potent inhibitor among tested analogues against Staphylococcus aureus methicillin resistance with MIC value of 2.68 microM.
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