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Ribavirin: Biotechnological Synthesis and Effect on the Reproduction of Vaccinia Virus |
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| Authors: | Konstantinova I D Leont'eva N A Galegov G A Ryzhova O I Chuvikovskii D V Antonov K V Esipov R S Taran S A Verevkina K N Feofanov S A Miroshnikov A I |
| Institution: | (1) Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia;(2) Ivanovskii Institute of Virology, Russian Academy of Medical Sciences, ul. Gamalei 16, Moscow, 123098, Russia |
| Abstract: | The biotechnological method of synthesis of ribavirin, vidarabin, and 6-azauridine by the use of immobilized recombinant enzymatic preparations of nucleoside phosphorylase was improved. The effect of ribavirin and its combinations with the other synthesized nucleosides on the reproduction of Vaccinia virus was studied on the culture of Vero cells. The combination of ribavirin and vidarabin was shown to provide the antiviral effect at lesser concentrations than with these compounds taken separately. |
| Keywords: | 6-azauridine immobilized enzymes purine nucleoside phosphorylase ribavirin uridine phosphorylase Vaccinia virus vidarabin |
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