Activation of TRAIL‐DR5 pathway promotes sensorineural degeneration in the inner ear |
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| Authors: | Shyan‐Yuan Kao Vitor YR Soares Arthur G Kristiansen Konstantina M Stankovic |
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| Institution: | 1. Eaton Peabody Laboratories and Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA;2. Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA;3. Program in Speech and Hearing Bioscience and Technology, Harvard Medical School, Boston, MA, USA |
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| Abstract: | Tumor necrosis factor (TNF) family cytokines are important mediators of inflammation. Elevated levels of serum TNF‐α are associated with human sensorineural hearing loss via poorly understood mechanisms. We demonstrate, for the first time, expression of TNF‐related apoptosis‐inducing ligand (TRAIL) and its signaling death receptor 5 (DR5) in the murine inner ear and show that exogenous TRAIL can trigger hair cell and neuronal degeneration, which can be partly prevented with DR5‐blocking antibodies. |
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| Keywords: |
TRAIL
DR5
OPG
cochlea hair cells spiral ganglion neuron |
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