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RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis
Institution:1. Department of Experimental Medical Science, Lund University, 221 00 Lund, Sweden;2. University of Tartu, Institute of Technology, 50411 Tartu, Estonia;3. Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, 901 87 Umeå, Sweden;4. Department of Clinical Microbiology, Rigshospitalet, 2200 Copenhagen, Denmark;5. Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, Bunkyo-ku, Tokyo 113-8656, Japan;6. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., Flemingovonam. 2, 166 10 Prague 6, Czech Republic;7. Faculty of Life Sciences, Kyoto Sangyo University, Kamigamo, Motoyama, Kita-ku, Kyoto 603-8555, Japan;8. Cellular and Molecular Microbiology (CM2), Faculté des Sciences, Université Libre de Bruxelles (ULB), Campus La Plaine, Building BC, Room 1C4203, Boulevard du Triomphe, 1050 Brussels, Belgium;9. WELBIO, Avenue Hippocrate 75, 1200 Brussels, Belgium
Abstract:
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  • Keywords:RelA-SpoT Homolog  toxin-antitoxin  tRNA modification  translation  (p)ppGpp  (p)ppApp  ribosome  toxSAS  SAS  SAH
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