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The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair
Affiliation:1. Department of Genetics, Harvard Medical School, and Division of Genetics, Brigham and Women’s Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA;2. Department of Medicine and Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA;3. Department of Radiation Oncology and Center for DNA Damage and Repair, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA;4. Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Abstract:
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  • Keywords:CRISPR  inter-strand crosslinks  resection  homologous recombination  replication stress  Protexin  SCAI  REV3L  FANCM  EXO1
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