In vitro interaction between glabridin and voriconazole against Aspergillus fumigatus isolates |
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| Affiliation: | 1. Faculty of Medicine, Sari Branch, Islamic Azad University, Sari, Iran;2. Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;3. Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran;4. Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran;5. Student Research Committee Center, Mazandaran University of Medical Sciences, Sari, Iran |
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| Abstract: | BackgroundVoriconazole (VRC) is widely recommended as the first-line therapy for invasive aspergillosis. However, surveillance studies have demonstrated that there is an increase in the frequency of azole resistance among Aspergillus fumigates isolates. In recent years, more studies on effective synergisms between natural agents and antifungal drugs have been published.AimsTo evaluate the synergistic antifungal effect of glabridin (Gla) and VRC against A. fumigatus isolates.MethodsPotential interactions between Gla and VRC were studied by using a microdilution checkerboard method based on the CLSI reference technique. To assess the interaction of drugs the fractional inhibitory concentration index (FICI) was calculated based on the Loewe Additivity model.ResultsThe minimum inhibitory concentrations (MIC) obtained with Gla alone were relatively high (MIC50 16 μg/ml). However, our results showed synergistic interaction between Gla and VRC against A. fumigatus strains, with FICI range values between 0.15 and 0.5.ConclusionsSynergistic activity of Gla and VRC against both VRC-sensitive and -resistant A. fumigatus isolates may lead to design new antifungal agents, especially for inhibiting those azole-resistant strains. |
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| Keywords: | Glabridin Voriconazole Synergism Glabridina Voriconazol Sinergia |
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