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Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis
Affiliation:1. Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Puddicombe Way, Cambridge CB2 0AW, UK;2. Department of Haematology, University of Cambridge, Cambridge CB2 0AW, UK;3. MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge CB2 0XZ, UK;4. Department of Haematology, Singapore General Hospital, Singapore, Singapore;5. Immunology Programme, The Babraham Institute, Cambridge CB22 3AT, UK;6. Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge CB20QQ, UK;7. Haematological Malignancy Diagnostic Service, St. James’s Institute of Oncology, Leeds LS9 7TF, UK;8. Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York YO10 5DD, UK;9. Department of Medicine II, Hematology/Oncology, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany;10. German Cancer Research Center and German Cancer Consortium, Heidelberg, Germany;11. Frankfurt Cancer Institute, Goethe University Frankfurt, 60596 Frankfurt, Germany;12. The Francis Crick Institute, London NW1 1AT, UK;13. Department for Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK;14. School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, Singapore;15. National Horizons Centre, Teesside University, 38 John Dixon Lane, Darlington DL1 1HG, UK;16. Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK;17. School of Health & Life Sciences, Teesside University, Middlesbrough TS1 3BA, UK;18. CEITEC, Masaryk University, Brno, Czech Republic;19. Department of Clinical Translational Research, Singapore General Hospital, Outram Road, Singapore 169856, Singapore;20. Department of Paediatric Oncology, Addenbrooke’s Hospital, Cambridge, UK;21. Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK;22. Section of Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, Leeds LS2 9JT, UK
Abstract:
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  • Keywords:DDX3X  MYC  RNA helicase  Burkitt lymphoma  germinal center  translation  proteotoxic stress
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