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Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
Affiliation:1. Department of Cancer Biology, Wake Forest Baptist Medical Center, Wake Forest University, Winston-Salem, NC 27101, USA;2. University of Arkansas for Medical Sciences, College of Pharmacy, Division of Pharmaceutical Science, 200 South Cedar, Little Rock, AR 72202, USA;3. Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA;4. Center for Metabolic and Vascular Biology, School of Nutrition and Health Promotion, College of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA;5. Chongqing Engineering Laboratory of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, IATTI, Chongqing University of Arts and Sciences, Yongchuan, Chongqing 402160, China;6. Atkins High School, Winston-Salem, NC 27101, USA
Abstract:
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  • Keywords:inositol  IMPA1  AMPK  mitochondrial fission  mitocondrial dynamics  AMP  glucose deprivation  inosiotl sensor  energy stress  inositol/AMP ratio
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