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Epigenetic reprogramming mechanisms of immunity during influenza A virus infection
Affiliation:1. The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran;2. Department of Influenza and Other Respiratory Viruses, Pasteur Institute of Iran, Tehran, Iran;3. Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;4. Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran;1. Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco;2. Faculté de Médecine de Casablanca, CHU Ibn Rochd, Casablanca, Morocco;3. Unité “Organisation Nucléaire et Oncogenèse”, INSERM U993, Institut Pasteur, Paris, France;1. Institute of Cytology, RAS, St Petersburg, Russia;2. Institute of Molecular Genetics of National Research Center “Kurchatov Institute”, RAS, Moscow, Russia;3. Demidov Yaroslavl State University, Yaroslavl, Russia;1. Infectious Diseases Division, Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”, Calz. México-Xochimilco No. 289, Col. Arenal de Guadalupe, Ciudad de México 14389, Mexico;2. Plan de Estudios Combinados en Medicina (PECEM) MD/PhD, Facultad de Medicina, Universidad Nacional Autónoma de México, Circuito Interior, Ciudad Universitaria, Av. Universidad 3000, Ciudad de México 04510, Mexico
Abstract:This paper reviews epigenetic mechanisms by which influenza viruses affect cellular gene activity to control their life cycles, aiming to provide new insights into the complexity of functional interactions between viral and cellular factors, as well as to introduce novel targets for therapeutic intervention and vaccine development against influenza infections.
Keywords:Epigenetic  Gene expression  Influenza A virus  Antiviral strategy
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