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Structure,mechanism, and inhibition of Hedgehog acyltransferase
Institution:1. Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK;2. Department of Chemistry, Imperial College London, 82 Wood Lane, London W12 0BZ, UK;3. Department of Biochemistry, University of Oxford, University of Oxford, South Parks Road, Oxford OX1 3QU, UK;4. Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Pleinlaan 2, 1050 Brussels, Belgium;5. VIB-VUB Center for Structural Biology, Vlaams Instituut Biotechnologie (VIB), Pleinlaan 2, 1050 Brussels, Belgium;6. National Heart and Lung Institute, Imperial College London, Exhibition Road, London SW7 2AZ, UK;7. Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
Abstract:
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  • Keywords:Sonic Hedgehog signaling  Hedgehog acyl transferase  membrane-bound O-acyltransferase  heme  palmitoyl co enzyme A  cryo-EM structure  molecular dynamics simulations  integral membrane protein  small molecule inhibitor  drug
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