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Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2
Affiliation:1. Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan;2. Department of Biochemistry, Asahikawa Medical University, Midorigaoka-Higashi, Asahikawa 078-8510, Japan;3. MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK;4. Department of Chemistry, Graduate School of Science, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan;5. Graduate School of Medical Life Science, Yokohama City University, 1-7-29, Tsurumi, Yokohama 230-0045, Japan
Abstract:
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  • Keywords:P-type ATPase  ATP13A2  cryo-EM  MD simulation  PARK9  polyamine  P5B-ATPase  lysosome  Parkinson's disease  membrane protein
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