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A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization
Institution:1. Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece;2. Genome Integrity Group, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark;3. Translational Epigenetics Group, Institute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany;4. Unit of Bioinformatics and Applied Genomics, Department of Microbiology, Hellenic Pasteur Institute, 11521 Athens, Greece;5. Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 77 Solna, Stockholm, Sweden;6. Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA;7. Nucleolar Stress and Disease Group, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark;8. Laboratories of Biology, Medical School, University of Patras, 26504 Rio, Greece;9. University of Groningen (RUG), European Research Institute for the Biology of Aging (ERIBA), University Medical Center Groningen (UMCG), 9713 AV Groningen, the Netherlands;10. Department of Pathology, NYU School of Medicine, New York, NY 10016, USA;11. DNA Replication and Cancer Group, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark;12. Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany;13. Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece;14. Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine & Health, University of Manchester, M20 4GJ Manchester, UK;15. Center for New Biotechnologies and Precision Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece;16. Faculty of Health and Medical Sciences, University of Surrey, Surrey GU2 7YH, UK
Abstract:
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  • Keywords:DNA damage  senescence  cancer  DNA replication  Hi-C  chromatin loop  replication stress
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