Fibroblast growth factor receptor 2 gene (FGFR2) rs2981582T/C polymorphism and susceptibility to breast cancer in Saudi women |
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| Authors: | Rawya Ibrahim Rabeh AlRaddadi Razan Jamaan Nafaa Alamri Weam Talal Yehya Shebli Emad Ibrahim Yagoub Fallatah Ahmed Safar Alhujaily Hiba Salaheldin Mohamed Mohammad Kdaimes H. Alotibi |
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| Affiliation: | 1. Department of Biology, College of Science, Taibah University, Madinah, Saudi Arabia;2. Department of Oncology, King Fahad Hospital, Madinah, Saudi Arabia;3. Department of Pathology, King Fahad Hospital, Madinah, Saudi Arabia;4. Institute of Endemic Diseases. University of Khartoum, Sudan |
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| Abstract: | Fibroblast growth factor receptor 2 is a protein encoded by FGFR2 gene and plays an important role in cellular growth. This study was conducted to investigate a potential association of FGFR2 rs2981582 with breast cancer. DNA was obtained from 137 Formalin-fixed, paraffin-embedded tumors and 98 normal breast tissue samples. Genotypes were carried out with PCR-RFLP. The odds ratio and 95% confidence interval (CI) were used to evaluate the power of the associations. A significant association between FGFR2 rs2981582 C allele and susceptibility to breast cancer was found (p-value < 0.0001, Odds Ratio = 2.3, %95 CI (1.5–3.0). No significant differences in FGFR2 rs2981582 genotypes and alleles distribution among breast patients with different hormonal receptor status (p > 0.05) were detected. However, a significant difference was found in genotypes and alleles distribution in ER+, PR- and HER2 between breast cancer cases and controls. This study showed an association of FGFR2 rs2981582T/C with breast cancer in Saudi women, further large study is required to validate the results. |
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| Keywords: | Gene FGFR2 rs2981582 Breast cancer Saudi Arabia |
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