2-hydroxyestrone induced rise in serum luteinizing hormone in the immature male rat. |
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| Authors: | F Naftolin H Morishita I J Davies R Todd K J Ryan |
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| Affiliation: | Harvard Medical School Department of Obstetrics and Gynecology Laboratory of Human Reproduction and Reproductive Biology 45 Shattuck Street Boston, Massachusetts 02115, USA;Institute of Steroid Research Montefiore Hospital and Medical Center 111 East 210th Street Bronx, New York 10467, USA |
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| Abstract: | Subcutaneous injection of 50 or 100 μg of 2-hydroxyestrone in 35 day old male rats resulted in a dramatic (4–7 fold) rise in serum luteinizing hormone at 6 hours post treatment. Estrone in similar doses (1–200 μg) caused a small decrease in serum luteinizing hormone which was not statistically significant. The discrepancy between the actions of naturally occurring estrogens may be useful in explaining the time and dose related biphasic effects of estrogens on gonadotropin levels. |
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