Effects of low testosterone levels and of adrenal androgens on growth of prostate tumor models in nude mice |
| |
Authors: | W.W. van Weerden, G.J. van Steenbrugge, A. van Kreuningen, E.P.C.M. Moerings, F.H. De Jong,F.H. Schr der |
| |
Affiliation: | a Department of Urology, Erasmus University, Rotterdam, The Netherlands b Department of Biochemistry II, Erasmus University, Rotterdam, The Netherlands |
| |
Abstract: | Two transplantable, androgen dependent prostate tumor models of human origin, PC-82 and PC-EW, were used to study the effect of low androgen levels and adrenal androgens on prostate tumor cell proliferation. Tumor load of the PC-82 and PC-EW tumors could be maintained constant when plasma testosterone levels were 0.8 and 0.9 nmol/l, respectively, corresponding with an intratissue 5-dihydrotestosterone level of 3–4 pmol/g tissue. This critical androgen level for prostate tumor growth stimulation amounted to 2–3 times the castration level and proved to be similar for both tumor models. Relatively high levels of androstenedione resulted in physiological levels of plasma testosterone causing androgen concentrations in PC-82 tumor tissue exceeding the critical level for tumor growth. These results indicate that submaximal suppression of androgens can stop tumor growth in these prostate tumor models. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|