The effect of tunicamycin on cell-surface changes associated with development and differentiation ofDictyostelium discoideum

Developmental changes in surface properties ofDictyostelium discoideum cells have been detected by partitioning. Changes occurring between 0 and 6 h development were not affected by tunicamycin but subsequent changes associated with formation of presumptive spore cells were inhibited. It would seem that only the latter changes are dependent on glyco-protein synthesis.