c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland |
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| Authors: | Tina Stoelzle Patrick Schwarb Andreas Trumpp and Nancy E Hynes |
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| Institution: | (1) Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland;(2) Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany;(3) HI-STEM (Heidelberg Institute for Stem Cell Technology and Experimental Medicine), Heidelberg, Germany |
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| Abstract: | Background The oncoprotein c-Myc has been intensely studied in breast cancer and mouse mammary tumor models, but relatively little is
known about the normal physiological role of c-Myc in the mammary gland. Here we investigated functions of c-Myc during mouse
mammary gland development using a conditional knockout approach. |
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