Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes |
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| Authors: | Steeve Kwan Tat Jean-Pierre Pelletier Nathalie Amiable Christelle Boileau Martin Lavigne Johanne Martel-Pelletier |
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| Institution: | (1) Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, H2L 4M1, Canada;(2) Department of Orthopaedic Surgery, Maisonneuve-Rosemont Hospital, 5345 boulevard l'Assomption, Montreal, Quebec, H1T 4B3, Canada |
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| Abstract: | Introduction Members of the ephrin system, the ephrin receptor erythropoietin-producing hepatocellular B4 (EphB4) and its specific ligand,
ephrin B2, appear to be involved in the bone remodelling process. We recently showed that their interaction inhibits the resorptive
activity of human osteoarthritic (OA) subchondral bone osteoblasts. Hence, we further investigated the possible implication
of these ephrin members on the catabolic/anabolic activities of human OA chondrocytes. |
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