难治性抑郁症的发病机制研究现状

抑郁症是一种高患病率、高致残率及高自杀率的严重精神疾患。在过去10年中,抗抑郁药物研究取得了突飞猛进的进展。然而,在临床上仍约有20%的抑郁症患者最终成为难治性抑郁症病例。难治性抑郁症是一种情感障碍,目前尚无较好的治疗策略。现对有关难治性抑郁症的病因学现状进行文献回顾与总结,了解难治性抑郁症的发病机制,便于从临床治疗角度早期识别该类患者,尽可能及早地给予积极的抗抑郁治疗,以提高临床缓解率。

On Pathogenesis of Treatment-Resistant Depression

Depression is a highly prevalent and disabling condition associated with significant morbidity and mortality.Although the therapeutic armamentarium available for clinicians treating depression patients has expanded substantially over the last decade,up to 20 % of depression patients eventually present with treatment-resistant depression(TRD).However,the optimal strategy for treating TRD has yet to be identified.TRD is a kind of affective disorders.We have reviewed and summarized the literatures about curren...