| 功能矫形前伸青春期大鼠下颌后浅层嚼肌细胞凋亡的研究 |
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| 引用本文： | 杜衍晓,杨竹丽,达雨,田臻,王梦佳,阎潇,郑如松,袁晓.功能矫形前伸青春期大鼠下颌后浅层嚼肌细胞凋亡的研究[J].现代生物医学进展,2011,11(6):1048-1051. |
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| 作者姓名： | 杜衍晓 杨竹丽 达雨 田臻 王梦佳 阎潇 郑如松 袁晓 |
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| 作者单位： | 1. 青岛大学医学院,山东,青岛,266021
2. 青岛市市立医院,山东,青岛,266071 |
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| 基金项目： | 国家自然科学基金，青岛市科技局科技支撑计划 |
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| 摘 要： | 目的:研究功能矫形前伸大鼠下颌后浅层嚼肌细胞凋亡的变化规律,探讨功能矫形的肌肉改建机理。方法:选用50只5周龄Sprague-Dawley(SD)雄性大白鼠,随机分为实验组和对照组各25只。实验组大鼠戴自制上颌功能矫治嚣,引导下颌前伸,并打开咬合。利用RT-PCR方法检测两组大鼠浅层嚼肌Bcl-2和Bax基因表达情况,利用TUNEL方法检测浅层嚼肌细胞凋亡情况。结果:①Bcl-2和Bax基因表达随大鼠戴用矫治器时间的延长而升高,至第3周开始下降但仍高于对照组,但Bax的表达高于Bcl-2。Bax/Bcl-2比值随大鼠戴用矫治器时间的延长而升高,至第4周开始下降。②TUNEL实验结果显示浅层嚼肌细胞在戴用矫治器1天后,开始出现凋亡,随着时间延长而增加,至第3周达到顶峰,第4周开始下降。结论:①Bax/Bcl-2比值升高促进浅层嚼肌细胞凋亡。②功能矫形可引起浅层嚼肌细胞凋亡,导致肌肉的结构和功能发生适应性改建。
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| 关 键 词： | 功能矫形 浅层嚼肌 细胞凋亡 |
Superficial Masseter Muscle Cells Apoptosis after Function Mandibular
Advancement in Juvenile Rats |
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| DU Yan-xiao,YANG Zhu-li,DA Yu,TIAN Zhen,WANG Meng-ji,YAN Xiao,ZHENG Ru-song,YUAN Xiao.Superficial Masseter Muscle Cells Apoptosis after Function Mandibular
Advancement in Juvenile Rats[J].Progress in Modern Biomedicine,2011,11(6):1048-1051. |
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| Authors: | DU Yan-xiao YANG Zhu-li DA Yu TIAN Zhen WANG Meng-ji YAN Xiao ZHENG Ru-song YUAN Xiao |
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| Institution: | DU Yan-xiao1,YANG Zhu-li2,DA Yu1,TIAN Zhen1,WANG Meng-jia1,YAN Xiao1,ZHENG Ru-song1,YUAN Xiao2(1 Affiliated Hospital of Qingdao University Medical College,Qingdao Municipal Hospital,Qingdao Shandong266021,China,2 Qingdao Municipal Hospital,266071,Qingdao,China) |
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| Abstract: | Objective:To investigate the relationship of the apoptotic superficial masseter muscle cells after functional mandibular advancement on juvenile rats.Methods:Fifty 5-week-old male Sprague-Dawley(SD) rats were randomly divided into experimental and control groups.The mimic functional appliances were used in experimental groups,and the rats of two groups were killed on 1st,7th,14th,21th,28th day.The erminal deoxynucleotidyl transferase-mediated deoxyuridine 5-triphosphate nick and labeling(TUNEL) and Hoechst ... |
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| Keywords: | Functional orthopedics Superficial masseter muscles Apoptotic |
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